The chitosan application of IVO-PLGA-NPs was proved by an increase in mean particle size and confirming ZP value . Because of the chitosan coating , the IVO-CS-PLGA-NPs evinced a more stable and drawn-out going of IVO than IVO-PLGA-NPs . In comparability to pure-IVO , the IVO-PLGA-NPs and IVO-CS-PLGA-NPs were found to be more efficacious