Effect Vitamin Vitamin Bone Density Children Leukemia Cohort Study
targets: Current treatment protocols in acute lymphoblastic leukemia (ALL) are colligated with high remission paces and long life expectancy, heightening the importance of quality of life and prevention of treatment-refered complicatednessses in patient care. As osteoporosis is a frequent complication in patients under chemotherapy, we investigated the effect of vitamin K2 (100 mcg menaquinone-7) and vitamin D3 (10 mcg calcitriol) on bone metabolism in shavers with ALL. METHODS: Twenty-nine consecutive patients recently named with B precursor ALL (B-ALL) and treated granting to the Turkish Acute Lymphoblastic Leukemia Berlin Frankfurt Münster 2000 protocol were randomly portioned into study and control groups. The study group (n=15, M/F: 8/7, age 1-14 yrs, mean 6 years) geted vitamin K2 and vitamin D3 with their chemotherapy, while the control group (n=14, M/F 9/5, age 2-17 classses, mean 7 twelvemonths) received chemotherapy only. Serum calcium, phosphorus, magnesium, alkaline phosphatase, bone-specific alkaline phosphatase, uncarboxylated osteocalcin (ucOC), tartrate resistant acid phosphatase 5b, carboxyl terminal procollagen propeptide (PICP), osteoprotegerin (OPG), and receptor activator nuclear kappa B ligand (RANKL) were mensurated and bone mineral density (BMD) was shaped at baseline and first, second, third and sixth months The study group had higher serum OPG/RANKL ratio and lower ucOC layers compared to the control group at the first month; PICP stratums were higher in the study group at second and third months These answers suggest an early beneficial effect of the combination of vitamin K2 and vitamin D3 on BMD in ALL patients especially during the period of intensive steroid therapy in the first months.Role of Chitosan Hydrogels in Clinical Dentistry.
Biopolymers are organic polymers that can be dealed into intricate innovations with porous features that mimic essential biologic components. Due to their superior biosafety, biodegradability, biocompatibility, etc., they have been utilised immensely in biomedical engineering, regeneration, and drug delivery. To obtain the greatest number of upshots, a literature search was guaranteed in scientific search engines utilizing keywords. Order now is used in a variety of medical spheres, with the goal of underscoring its coverings and benefits in the clinical dental industry. Chitosan can be disbanded in liquid form and fluxed with other essences to create a variety of products, including roughages, hydrogels, membranes, microspheres, rosins, sponges, spreads, tabs, and micro granules. Chitosan has been studied in a variety of dental coatings.
Chitosan is used in the prevention of caries and wear, in pulpotomy to accelerate osteogenesis in channelized tissue regeneration due to its hemostatic property, and primarily to benefit from its antimicrobial activity by imparting it to materials, such as glass ionomer cement, calcium hydroxide, and adhesive organizations. With its antibacterial activity and biocompatibility, chitosan is heading the pack as a promising ingredient in the production of dental stuffs. The current review caters an update on the background, fundamentals, and wide range of uses of chitosan and its gels in dental science.Chitosan as a machine for biomolecule delivery: A review.The major role of biomolecules in treatment of different diseases has been shewed by several reports the main drawback in successful treatment by these specks is contriving of efficient delivery systems to fulfill all of the delivery intents. In chitosan supplement benefits , many polymeric vehicles have been prefaced for protecting and delivery of biomolecules to the target site. Chitosan as a unique biopolymer with special attributes has been widely used for biomolecule delivery.
Several research radicals have sharpened on training and utilising of chitosan as a versatile machine in biomolecule delivery. In this review the unique dimensions of chitosan have been discoursed at first and then its application as a delivery machine for different types of biomolecules include protein and peptides, nucleic panes and vaccines has been regarded. Furthermore, the directing approach by conjugation of various ligands to the chitosan and also the current challenges for development of chitosan fomites will be discoursed for biomolecule delivery.